The Pipe Creek Wildlife Area is located within the city limits of Sandusky, behind the Big Island water treatment facility. It overlooks Sandusky Bay. The area can be reached by following U.S. Route 6 to Sandusky, turn north onto Cedar Point Causeway, then east onto River Avenue; or follow State Route 4 to Sandusky, turn northeast onto Monroe Street, then east onto First Street, then south onto F Street.
The 97-acre area is situated on the former Big Island Wetland Complex on the southern shore of Sandusky Bay. Most of the area is a diked marsh, with the remaining acreage comprising flat-topped dikes. The marsh areas are shallow, varying from one to three feet in depth, with the exception of channels up to eight feet in depth which were created for efficient water level control of the area.